Sodium Carbonate → 4-Ethoxybut-2-yn-1-ol

HRID 237862

반응식

HRID 237862 반응식
[CH2:1]([O:3][CH2:4][C:5]#[C:6][CH2:7][O:8][CH:9]1[CH2:14]CCC[O:10]1)[CH3:2].O.[C:16]1(C)[CH:21]=[CH:20][C:19](S(O)(=O)=O)=[CH:18][CH:17]=1.C(=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:7][O:8][C:9]([CH3:14])=[O:10].[CH3:20][CH2:21][CH2:16][CH2:17][CH2:18][CH3:19].[CH2:1]([O:3][CH2:4][C:5]#[C:6][CH2:7][OH:8])[CH3:2]

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 521998p-Toluenesulfonic acid monohydrateHCID 685294632-(4-Ethoxy-but-2-ynyloxy)-tetrahydro-pyran

생성물 2

HCID 127868104-Ethoxybut-2-yn-1-ol수율 385.9%HCID 23449302Methyl acetate hexane수율 1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-(4-ethoxy-but-2-ynyloxy)-tetrahydro-pyran (0.5 g, 2.52 mmol) in methanol (10 mL) was added p-toluenesulfonic acid monohydrate (p-TSOH) (0.086 g, 0.454 mmol). The reaction mixture was stirred at room temperature for 3.5 hours. The reaction mixture was poured into aqueous sodium carbonate and extracted with methyl acetate. The organic layers were combined, dried (Na2SO4) and concentrated. Silica gel chromatography (1-10% MeOAc/hexane) provided 0.2 g of 4-ethoxy-but-2-yn-1-ol as a clear oil.

후처리

  1. extractionextracted with methyl acetate
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-04be88845d1f4d6d9b54e5d1406b7d8f
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642603B2

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