4-Dimethoxymethyl-1-(2-morpholinoethoxy)-2-nitrobenzene → 5-Dimethoxymethyl-2-(2-morpholinoethoxy)aniline

HRID 2378718노트

반응식

HRID 2378718 반응식
[CH3:1][O:2][CH:3]([O:22][CH3:23])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[C:6]([N+:19]([O-])=O)[CH:5]=1>C(O)C.[Pt]=O>[CH3:1][O:2][CH:3]([O:22][CH3:23])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)=[C:6]([CH:5]=1)[NH2:19]

참가 물질

4

반응물 1

HCID 231179024-Dimethoxymethyl-1-(2-morpholinoethoxy)-2-nitrobenzene

생성물 1

HCID 231179015-Dimethoxymethyl-2-(2-morpholinoethoxy)aniline수율 26%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A solution of 4-dimethoxymethyl-1-(2-morpholinoethoxy)-2-nitrobenzene obtained in Step 2 (2.97 g, 9.10 mmol) in ethanol (30.0 mL) was added with platinum oxide (0.02 g, 0.10 mmol), followed by stirring at room temperature under hydrogen atmosphere for 2 hours. The reaction mixture was filtered, the solvent of filtrate was evaporated under reduced pressure, the resulting crude product was crystallized from mixed solvent of ethyl acetate/hexane (1/1) to obtain 5-dimethoxymethyl-2-(2-morpholinoethoxy)aniline (0.70 g, 26%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of filtrate was evaporated under reduced pressure
  3. customthe resulting crude product was crystallized
  4. additionfrom mixed solvent of ethyl acetate/hexane (1/1)

출처 및 근거

ORD 기록
ord-f0902de9772741c9a7374aa3f6ed398c
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470717B2

반응 노트

불러오는 중…