(+)-Benzyl glycidyl ether → HCID 68527184, 화합물

HRID 237879노트

반응식

HRID 237879 반응식
[N:1]#[C:2][NH2:3].[Na].[CH2:5]([O:12][CH2:13][C@@H:14]1[CH2:16][O:15]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[CH2:5]([O:12][CH2:13][C@H:14]1[O:15][C:2]([NH2:3])=[N:1][CH2:16]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 146296(+)-Benzyl glycidyl etherHCID 57375518Cyanamidnatrium

생성물 1

HCID 68527184HCID 68527184, 화합물수율 96%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a vigorously stirred solution of sodium hydrogen cyanamide (1.95 g, 30.4 mmol) in methanol (30.5 mL) was added dropwise (S)-2-benzyloxymethyl-oxirane (5 g, 30.4 mmol) in methanol. The reaction mixture was stirred at room temperature overnight after which the reaction mixture was concentrated to remove methanol. Ethyl acetate was added (150 mL) along with 50 ml of water. The contents were transferred to a separatory funnel, the organic layer was removed, dried over Na2SO4 and concentrated under vacuum to give 6.01 g (96%) of the title compound.

후처리

  1. concentrationwas concentrated
  2. customto remove methanol
  3. additionEthyl acetate was added (150 mL) along with 50 ml of water
  4. customThe contents were transferred to a separatory funnel
  5. customthe organic layer was removed
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-babb6067cdf046538ca41461844b2546
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642603B2

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