Ethyl propiolate → HCID 59252478, 화합물

HRID 237886노트

반응식

HRID 237886 반응식
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH:15]3[O:19][C:18]([NH2:20])=[N:17][CH2:16]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:21](OCC)(=[O:24])[C:22]#[CH:23]>C(O)C>[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH:15]3[O:19][C:18]4=[N:20][C:21](=[O:24])[CH:22]=[CH:23][N:17]4[CH2:16]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 12182Ethyl propiolateHCID 68529232HCID 68529232, 화합물

생성물 1

HCID 59252478HCID 59252478, 화합물수율 217.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-[(4-cyclohexyl-phenylamino)-methyl]-4,5-dihydro-oxazol-2-ylamine (1.13 g, 4.14 mmol) in 50 ml of ethanol was added 0.42 ml (0.415 mmol) of ethyl propiolate. The mixture was stirred at reflux for 6 h under nitrogen after which it was allowed to cool to room temperature. The resulting white crystals were isolated by filtration, washed with ethanol, and dried at room temperature under high vacuum to provide 0.294 g of the title compound. The filtrate from the filtration was concentrated to 10 ml and allowed to stand for 6 h. The resulting white crystals were isolated by filtration and dried under high vacuum to provide an additional 0.059 g of the title compound.

후처리

  1. temperatureat reflux for 6 h under nitrogen after which it
  2. customThe resulting white crystals were isolated by filtration
  3. washwashed with ethanol
  4. customdried at room temperature under high vacuum

출처 및 근거

ORD 기록
ord-4b4a5d165c764e05a5fcb78aa7c54a33
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642603B2

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