Toluene → [2,3-Quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester

HRID 2379025

반응식

HRID 2379025 반응식
[N:1]1[C:10]2[C:5](=[CH:6]C=C[CH:9]=2)[N:4]=CC=1.C[O:12][P:13]([O:16][CH3:17])[O:14][CH3:15].[C:18]1(C)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:15][O:14][P:13]([CH2:6][C:5]1[C:10]([CH2:9][P:13](=[O:12])([O:16][CH3:17])[O:14][CH3:15])=[N:1][C:18]2[C:19]([N:4]=1)=[CH:20][CH:21]=[CH:22][CH:23]=2)(=[O:12])[O:16][CH3:17]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 7045QuinoxalineHCID 8472Trimethyl phosphite

생성물 1

HCID 86747692[2,3-Quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester

실험 절차

This known compound is prepared by making a solution of quinoxaline (3.16 g, 10 mmol) in hot toluene (20 ml) and treating with trimethylphosphite (2.73 g, 22 mmol). The mixture is heated at reflux temperature for 24 hours. The cooled solution deposits [2,3-quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester (2.70 g, m.p. 113°-114° C.) after recrystallization from toluene. V. A. Arbuzov et al. Izvest Acad. Nauk SSSR, 1961, 1016; 1954, E 868; (Chem Abstracts (CA) 55:27352b; CA 49:13222e) report a m.p. 115°-116° C.

후처리

  1. customThis known compound is prepared
  2. temperatureThe mixture is heated
  3. temperatureat reflux temperature for 24 hours
  4. customThe cooled solution deposits [2,3-quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester (2.70 g, m.p. 113°-114° C.) after recrystallization from toluene

출처 및 근거

ORD 기록
ord-f34d2c28a3e748239ebc0e43af627408
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05360797

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