1,4-Dioxane → 3,4,5,6,-Tetrahydro-6-methylazepino[4,3-b]indol-1(2H)-one

반응식

[CH3:1][N:2]1[C:14]2[CH2:13][CH2:12][CH2:11][C:10](=[N:15]O)[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.[O:17]1CCOCC1>>[CH3:1][N:2]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=2[C:9]2[C:10](=[O:17])[NH:15][CH2:11][CH2:12][CH2:13][C:14]1=2

참가 물질

반응물 2

HCID 312751,4-Dioxane

HCID 701900HCID 701900, 화합물

생성물 1

HCID 156163063,4,5,6,-Tetrahydro-6-methylazepino[4,3-b]indol-1(2H)-one

실험 절차

1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one oxime (24 g) and polyphosphoric acid (600 g) in dioxan (500 ml) were treated according to the method described for Intermediate 6. The solid (22 g) obtained by evaporation of the organic extracts was recrystallised from ethyl acetate (300 ml) to give a solid (19.2 g). This was purified by FCC eluting with System A (200:8:1) to give the title compound (5.5 g), m.p. 212°-215°.

출처 및 근거

ORD 기록: ord-5ec85e6ff1664347895a7534ff569cb2
출처 데이터셋: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05360800

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