Butyric Acid → 4-Butanoylresorcinol

HRID 2379171

반응식

HRID 2379171 반응식
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[C:9](O)(=[O:13])[CH2:10][CH2:11][CH3:12].Cl.[Cl-].[Na+].O>ClCCCl.[Cl-].[Cl-].[Zn+2]>[C:9]([C:6]1[CH:7]=[CH:8][C:1]([OH:2])=[CH:3][C:4]=1[OH:5])(=[O:13])[CH2:10][CH2:11][CH3:12]

참가 물질

6

반응물 3

HCID 264Butyric AcidHCID 5054ResorcinolHCID 131718760Hydrochloric acid brine

생성물 1

HCID 781034-Butanoylresorcinol

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 111,2-Dichloroethane용매

반응 조건

온도
150 °C

실험 절차

To a solution of resorcinol (1.5 g) and butyric acid (2.9 mL) in 1,2-dichloroethane (45 mL) was added ZnCl2 (3.22 g) and the mixture then heated at 150° C. under nitrogen for 5 hr. The reaction mixture was cooled, poured onto 1N HCl/brine and extracted (3x EtOAc). After washing with 0.1N K2CO3, then twice with brine, the organic layer was dried and evaporated. Chromatography of the residue (silica gel; hexane/EtOAc 2:1) afforded the title product as a solid.

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted (3x EtOAc)
  3. washAfter washing with 0.1N K2CO3
  4. dry with materialtwice with brine, the organic layer was dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-bf0c04924124472d9d82c72dd027406c
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05360815

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