[2-(4-Bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane → (3-{[{4-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-benzyl}-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester

HRID 23796

반응식

HRID 23796 반응식
[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])=[CH:31][CH:30]=1>>[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:39])[CH3:40])=[CH:33][CH:34]=2)[S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 22590501[2-(4-Bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silaneHCID 69730626{3-[(Pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester

생성물 1

HCID 69729909(3-{[{4-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-benzyl}-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester

실험 절차

The title compound was prepared by alkylation of {3-[(pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester (122 mg, 0.322 mmol) with [2-(4-bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane (121 mg, 0.339 mmol) following the procedure described for Example 1, Step A. The reaction time was 1 h. The crude product (238 mg) was used in the next step without purification. MS 655 (M+1).

후처리

  1. customThe crude product (238 mg) was used in the next step without purification

출처 및 근거

ORD 기록
ord-a1b03d1712dd49f2bbd9af9fca405b29
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852863B2

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