[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][CH2:7][C:8]1[N:13]=[C:12]([C:14]2[N:15]=[C:16]([N:19]=[C:20]([NH2:22])[NH2:21])[S:17][CH:18]=2)[CH:11]=[CH:10][CH:9]=1.N1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>ClCCl.O.C(OCC)(=O)C.O1CCCC1>[NH2:21][C:20](=[N:19][C:16]1[S:17][CH:18]=[C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][NH:6][S:2]([CH3:1])(=[O:4])=[O:3])[N:13]=2)[N:15]=1)[NH2:22]Methanesulfonyl chloride (0.58 ml) was added a mixture of 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (1.8 g) and pyridine (0.81 ml) in dichloromethane (40 ml) under ice-cooling and the mixture was stirred for 23 hours at ambient temperature. The reaction mixture was added a mixture of tetrahydrofuran, ethyl acetate and water and the mixture was adjusted to pH 9.5 with 20% aqueous potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated. The residue was recrystallized-from an aqueous methanol to give 2-(diaminomethyleneamino)-4-(6-methanesulfonylaminomethylpyridin-2-yl)thiazole (0.4 g).
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