Tetrahydrofuran → 2-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

HRID 2380055노트

반응식

HRID 2380055 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH3:11].O1CCC[CH2:20]1>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[CH2:20][O:18]1

참가 물질

4

반응물 2

HCID 8028Tetrahydrofuran2회HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

생성물 1

HCID 189565362-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of dimethylsulphoxonium methylide (36.5 ml of a 0.6M solution in tetrahydrofuran) was added dropwise to a stirred solution of the product of part (ii) (4.36 g) in tetrahydrofuran (35 ml) at -20°. The solution was allowed to warm to room temperature and stirring was continued for 18 hours and then diluted with water. The mixture was extracted with ethyl acetate and the combined extracts were dried (Na2SO4). Evaporation of the solvent gave the title compound as an oil (4.50 g) which was used directly in the next stage.

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. dry with materialthe combined extracts were dried (Na2SO4)
  3. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-dda4588133a049e2b524c2b4358c2a79
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05364938

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