Oxalyl chloride → 3-Fluoro-5-methoxybenzoyl chloride
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:5](O)=[O:6].C(Cl)(=O)C([Cl:16])=O>C(Cl)Cl.CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:5]([Cl:16])=[O:6]참가 물질
5
실험 절차
3-fluoro-5-methoxybenzoic acid (5 g, 0.029 mol) was stirred in CH2Cl2 (50 ml) at 0° C. under an argon atmosphere. DMF (9 drops, catalytic) was added, followed by oxalyl chloride (12.7 ml, 0.147 mol). Reaction was warmed to room temperature then stirred under argon for one hour. Reaction was concentrated in vacuo to yield 3-fluoro-5-methoxybenzoyl chloride (BA67).
후처리
- customReaction
- customReaction
- concentrationwas concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-81bed34386834e2b92b6b3f50f89cbd0
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642604B2
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