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Ethylamine → N-(2-Bromo-6-methoxy-3-pyridinyl)-2-ethylamino-N-methyl-3-pyridinecarboxamide

HRID 2380239
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HRID 2380239 반응식
[CH2:1]([NH2:3])[CH3:2].[Br:4][C:5]1[C:10]([N:11]([CH3:21])[C:12]([C:14]2[C:15](Cl)=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:9][CH:8]=[C:7]([O:22][CH3:23])[N:6]=1>C1(C)C(C)=CC=CC=1.C(OCC)(=O)C>[Br:4][C:5]1[C:10]([N:11]([CH3:21])[C:12]([C:14]2[C:15]([NH:3][CH2:1][CH3:2])=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:9][CH:8]=[C:7]([O:22][CH3:23])[N:6]=1
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참가 물질

5

반응물 2

HCID 6341EthylamineHCID 10737014N-(2-Bromo-6-methoxy-3-pyridinyl)-2-chloro-N-methyl-3-pyridinecarboxamide

생성물 1

HCID 10618812N-(2-Bromo-6-methoxy-3-pyridinyl)-2-ethylamino-N-methyl-3-pyridinecarboxamide수율 77.1%

시약·촉매·용매 2

HCID 7237O-Xylene용매HCID 8857Ethyl Acetate용매

반응 조건

온도
150 °C

실험 절차

Ethylamine (0.7 g) was added to a solution of N-(2-bromo-6-methoxy-3-pyridinyl)-2-chloro-N-methyl-3-pyridinecarboxamide (1.9 g) in xylene (5 ml), and the resulting mixture was sealed in a pressure bottle and heated at 150° C. for 4 hours. The solution was diluted with ethyl acetate, washed with water, dried (anhydrous magnesium sulfate), concentrated, and purified on a silica gel column (ethyl acetate/hexane, 1:4) to give 1.5 g of the title compound, suitable for use in the next reaction.

후처리

  1. customthe resulting mixture was sealed in a pressure bottle
  2. washwashed with water
  3. dry with materialdried (anhydrous magnesium sulfate)
  4. concentrationconcentrated
  5. custompurified on a silica gel column (ethyl acetate/hexane, 1:4)

출처 및 근거

ORD 기록
ord-c36cce7cfc32406bac5922cdb5e49b2f
출처 데이터셋
uspto-grants-1994_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05366972

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