6-Bromohexanenitrile → 6-[(4,6-Diphenyl-2-pyridyl)oxy]hexanonitrile

HRID 2380329

반응식

HRID 2380329 반응식
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][C:9](=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]#[N:27]>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:10]=[C:9]([O:19][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]#[N:27])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 810936-BromohexanenitrileHCID 38462014,6-Diphenyl-2-pyridone

생성물 1

HCID 103374486-[(4,6-Diphenyl-2-pyridyl)oxy]hexanonitrile

시약·촉매·용매 2

HCID 178418647HCID 178418647, 화합물촉매HCID 1140Toluene용매

실험 절차

The procedure of Example 4 is followed using 4,6-diphenyl-2-pyridone (6.18 g) and 6-bromohexanonitrile (6.60 g) in place of 6-bromohexanoate, silver carbonate (6.89 g) and toluene (300 cc) and the reaction mixture is refluxed for 72 hours. The material formed is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 9.5-0.5) to obtain 6-[(4,6-diphenyl-2-pyridyl)oxy]hexanonitrile as a white solid which is used directly in subsequent reactions.

후처리

  1. temperaturethe reaction mixture is refluxed for 72 hours
  2. customThe material formed
  3. customis purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 9.5-0.5)

출처 및 근거

ORD 기록
ord-44227dcbed574b8394712fbb0dc59a15
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05366982

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