Potassium Hydroxide → 2-Ethyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoic acid

HRID 2380352노트

반응식

HRID 2380352 반응식
[CH2:1]([CH:3]([CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:16]=[C:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:14]=1)[C:4]([O:6]C)=[O:5])[CH3:2].[OH-].[K+]>O.C(O)C>[CH2:1]([CH:3]([CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:16]=[C:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:14]=1)[C:4]([OH:6])=[O:5])[CH3:2]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 18987170Methyl 2-ethyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate

생성물 1

HCID 189873362-Ethyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

The procedure in Example 6 is followed but using methyl 2-ethyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate (3.15 g), potassium hydroxide pellets (0.9 g) dissolved in distilled water (20 cc) and ethanol (100 cc). The reaction mixture is refluxed for 8 hours. The product is purified by recrystallisation in an n-hexane-ethyl acetate (2-1) mixture (40 cc), white crystals (m.p.=115° C.)

후처리

  1. temperatureThe reaction mixture is refluxed for 8 hours
  2. customThe product is purified by recrystallisation in an n-hexane-ethyl acetate (2-1) mixture (40 cc), white crystals (m.p.=115° C.)

출처 및 근거

ORD 기록
ord-ec5b5a2ec649494f9a2770e423d3b9f8
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05366982

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