4,6-Diphenyl-2-pyridone → Ethyl 2-ethyl-2-methyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate

HRID 2380353

반응식

HRID 2380353 반응식
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][C:9](=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][CH2:22][CH2:23][CH2:24][C:25]([CH2:32][CH3:33])([CH3:31])[C:26]([O:28][CH2:29][CH3:30])=[O:27]>C(=O)([O-])[O-].[Ag+2].CN(C)C=O>[CH2:32]([C:25]([CH3:31])([CH2:24][CH2:23][CH2:22][CH2:21][O:19][C:9]1[CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:12]=[C:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:10]=1)[C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH3:33]

참가 물질

5

반응물 2

HCID 38462014,6-Diphenyl-2-pyridoneHCID 18987177Ethyl 6-bromo-2-ethyl-2-methylhexanoate

생성물 1

HCID 18987342Ethyl 2-ethyl-2-methyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate

시약·촉매·용매 2

HCID 178418647HCID 178418647, 화합물촉매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

The procedure in Example 5 is followed but using 4,6-diphenyl-2-pyridinone (3 g), ethyl 6-bromo-2-ethyl-2-methylhexanoate (6.44 g) [prepared according to the method of K. E. MOELLER, Brenstoff-Chem., 47, 10 (1966)], silver carbonate (1.68 g) and dimethylformamide (110 cc). The reaction mixture is heated at 100° C. for 121 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 9-1).(yellow oil)

후처리

  1. customprepared
  2. customThe product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 9-1).(yellow oil)

출처 및 근거

ORD 기록
ord-b3aaf4b5f01c4f60a479992fba613d97
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05366982

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