2,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine → 6-(2-Fluorophenyl)pyridin-3-amine

HRID 2380399노트

반응식

HRID 2380399 반응식
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:3]=1>CO.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[N:3][CH:2]=1

참가 물질

4

반응물 1

HCID 189555872,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine

생성물 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a suspension of 2,4-dichloro-3 -nitro-6-(2-fluorophenyl)pyridine (1.6 g, 5.6 mmol) in methanol (100 ml) was added a catalytic amount of 10% palladium on carbon (100 mg). The mixture was hydrogenated at 50 psi for 8 hours then filtered through celite. The methanol was removed under reduced pressure and the residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate. The extract was washed with brine, dried over sodium sulfate, filtered and concentrated to give 5-amino-2-(2-fluorophenyl)pyridine, which was used without further purification.

후처리

  1. filtrationthen filtered through celite
  2. customThe methanol was removed under reduced pressure
  3. extractionthe residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate
  4. washThe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d6a4ffcff473467aa90dfde6a9ee9727
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05367077

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