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2,4-Di-tert-butylphenol → 3-(4-Hydroxy-3,5-dimethylphenyl)-5,7-bis(2-methyl-2-propanyl)-1-benzofuran-2(3H)-one

HRID 2380721
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인쇄 미리보기

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HRID 2380721 반응식
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[CH3:16][C:17]1[CH:18]=[C:19]([CH:25]=[C:26]([CH3:29])[C:27]=1[OH:28])[CH:20](O)[C:21](O)=[O:22]>C(O)(=O)C.CS(O)(=O)=O>[CH3:16][C:17]1[CH:18]=[C:19]([CH:20]2[C:7]3[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=3[O:15][C:21]2=[O:22])[CH:25]=[C:26]([CH3:29])[C:27]=1[OH:28]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 73112,4-Di-tert-butylphenolHCID 18991409100304-49-2

생성물 1

HCID 111006493-(4-Hydroxy-3,5-dimethylphenyl)-5,7-bis(2-methyl-2-propanyl)-1-benzofuran-2(3H)-one수율 88.1%

시약·촉매·용매 2

HCID 6395Methanesulfonic Acid촉매HCID 176Acetic Acid용매

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온도
95 °C

실험 절차

1.5 ml (23 mmol) of methanesulfonic acid are added to a mixture of 154.8 g (0.75 mol) of 2,4-di-tert-butylphenol and 98.1 g (0.50 mol) of 3,5-dimethyl-4-hydroxymandelic acid in 500 ml of acetic acid which is stirred at 95° C. under nitrogen. After about 4 minutes, crystallisation of the product in the form of fine, white crystals begins. The reaction mixture is refluxed for another hour, then cooled to about 15° C., and the precipitated product is filtered off. The residue is washed with 250 ml of acetic acid and with 1500 ml of water. Drying gives 161.5 g (88%) of 3-(3,5-dimethyl-4-hydroxyphenyl)-5,7-di-tert-butylbenzofuran-2-one, melting point 225°-228° C. (compound (107), Table 1).

후처리

  1. customcrystallisation of the product in the form of fine, white crystals
  2. temperatureThe reaction mixture is refluxed for another hour
  3. temperaturecooled to about 15° C.
  4. filtrationthe precipitated product is filtered off
  5. washThe residue is washed with 250 ml of acetic acid and with 1500 ml of water
  6. customDrying

출처 및 근거

ORD 기록
ord-52ec7ab7fbdd4513bb9759b2bbd557e1
출처 데이터셋
uspto-grants-1994_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05369159

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