Propylphosphonic anhydride → 2-[2-(Aminocarbonylmethoxy)-6-methoxyphenyl]-3-(2,6-dimethylphenylamino)-6-fluoroimidazo[1,2-a]pyridine

참여 물질

반응 조건

반응 단계

4.2 0.149 g of 12, 0.112 g of 2-amino-5-fluoropyridine 4, 0.209 g of 2-(2-formyl-3-methoxyphenoxy)acetamide 3, 0.286 ml of triethylamine and, dropwise, 2.5 ml of T3P® [=propylphosphonic anhydride (50% solution in ethyl acetate)] are introduced successively into a flask with ice-cooling and under an inert gas. The reaction mixture is stirred at 100° C. for 7 h. The mixture is subsequently subjected to conventional work-up, giving 0.2 g (40%) of “A1”.

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