(RS)-S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide → (RS)-S-(4-aminophenyl)-N-(2-methoxy-ethyl)-S-methylsulfoximide

HRID 238143노트

반응식

HRID 238143 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:16])(=[N:10][C:11](=O)[CH2:12][O:13][CH3:14])=[O:9])=[CH:4][CH:3]=1>O1CCCC1>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH3:16])(=[N:10][CH2:11][CH2:12][O:13][CH3:14])=[O:9])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 59550852(RS)-S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide

생성물 1

HCID 59550833(RS)-S-(4-aminophenyl)-N-(2-methoxy-ethyl)-S-methylsulfoximide수율 82.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

493 mg (2.03 mmol) (RS)—S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide is dissolved in 67.8 ml tetrahydrofuran, cooled in the ice-bath and treated dropwise with 6.13 ml (6.13 mmol) borane tetrahydrofuran complex. The mixture is stirred for 90 minutes and quenched with one drop of methanol and one drop of water. After chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate)), 383 mg (82%) of the desired product is obtained.

후처리

  1. additiontreated dropwise with 6.13 ml (6.13 mmol) borane tetrahydrofuran complex
  2. customquenched with one drop of methanol and one drop of water
  3. customAfter chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate))

출처 및 근거

ORD 기록
ord-38111730cf5f4fdf98e9ea3a58a436f1
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642611B2

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