Chlorosuccinimide → HCID 57990315, 화합물

HRID 2381651노트

반응식

HRID 2381651 반응식
[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.C1C(=O)N([Cl:23])C(=O)C1>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[C:10]([Cl:23])=[CH:9][NH:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 57990291HCID 57990291, 화합물

생성물 1

HCID 57990315HCID 57990315, 화합물수율 19.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (102 mg, 0.460 mmol) in CH2Cl2 (5 mL) at room temperature, NCS (68 mg, 0.51 mmol) was added. The mixture was stirred at reflux for 18 h. After being concentrated in vacuo, the residue was purified by HPLC to give 2,5-dichloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (23 mg).

후처리

  1. temperatureat reflux for 18 h
  2. concentrationAfter being concentrated in vacuo
  3. customthe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-03d66da8bbb74037832b6d8fe92de850
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258144B2

반응 노트

불러오는 중…