Sodium Azide → Methyl[1-(3-azidopropyl)cyclopropyl]acetate
반응식
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10]Br)[CH2:7][CH2:6]1.[N-:13]=[N+:14]=[N-:15].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][N:13]=[N+:14]=[N-:15])[CH2:7][CH2:6]1참가 물질
4
실험 절차
680 mg (2.89 mmol) of methyl[1-(3-bromopropyl)cyclopropyl]acetate and 1128 mg (17.35 mmol) of sodium azide in 5 ml of DMF were stirred at 60° C. for 2 h. The reaction mixture was then concentrated under reduced pressure. The residue was taken up in ethyl acetate and the solution was washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gave 389 mg (1.97 mmol, 68% of theory) of the title compound as a yellow oil.
후처리
- concentrationThe reaction mixture was then concentrated under reduced pressure
- washthe solution was washed with saturated sodium chloride solution
- dry with materialdried over anhydrous magnesium sulfate
- customRemoval of the solvent under reduced pressure
출처 및 근거
- ORD 기록
- ord-78b37aa043e64a5cb1534183f5ad0406
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642592B2
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