1,4-Diaminocyclohexane → 1-(4-(4-(4-(4-aminocyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

참여 물질

역할	이름	HCID	투입량
반응물	1,4-Diaminocyclohexane	HCID 18374	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	1-(4-(4-(4-(methylsulfinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone	HCID 69023141	—
용매	Dimethyl Sulfoxide	HCID 679	—
생성물	1-(4-(4-(4-(4-aminocyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone	HCID 57990390	13.1%

반응 조건

온도	116 °C

반응 단계

To a solution of 1-(4-(4-(4-(methylsulfinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone (34 mg, 0.085 mmol) in DMSO (1 mL), 1,4-diaminocyclohexane (cis and trans mixture, 35 mg, 0.31 mmol) and diisopropylethylamine (0.060 mL, 0.35 mmol) were added. The mixture was heated at 116° C. overnight. It was then purified by HPLC to give the titled compound (5 mg). MS 449.3 (M+H); UV 208.5, 265.1, 305.5 nm.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08258144B2
출처 데이터셋	uspto-grants-2012_09
ORD ID	ord-0da5395f070c43d79053ddf8c1830434
출처 메모	uspto-grants-2012_09