Ammonia → 2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.[NH3:12]>CCOC(C)=O>[Cl:1][C:2]1[N:3]=[C:4]([NH2:12])[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.1 g, 0.53 mmol) in Ammonia (7 N in MeOH, 1 mL) was heated at 100° C. for 24 h, then it was diluted with EtOAc, washed with Sat. NaHCO3, brine, dried and concentrated to give 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-amine (0.06 g).
후처리
- washwashed with Sat. NaHCO3, brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-2b733f6544884d5784e544974b3936fc
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08258144B2
반응 노트
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