Pentane → 3-(Phenyl(4-(trifluoromethyl)phenyl)methyl)piperidine

HRID 2382187

반응식

HRID 2382187 반응식
[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[C:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H].CCCCC>CO.[Pd]>[C:1]1([CH:7]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=2)[CH:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 8003PentaneHCID 687345843-(Phenyl(4-(trifluoromethyl)phenyl)methylene)piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 687345103-(Phenyl(4-(trifluoromethyl)phenyl)methyl)piperidine수율 99.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 3-(phenyl(4-(trifluoromethyl)phenyl)methylene)piperidine (1.0 g, 3.15 mmol) in methanol (25 mL) was charged with Pd/C under nitrogen atmosphere and fitted with hydrogen balloon using stopcock and covered with Teflon. The reaction mixture was stirred under hydrogen atmosphere for 8 h. It was filtered through celite, the celite was washed with methanol, and the solvent was removed under reduced pressure to afford the crude product which was then crashed out of pentane to give pure 3-(phenyl(4-(trifluoromethyl)phenyl)-methyl)piperidine (1.0 g, 98% yield) as a grey oil. MS (ESI, pos. ion) m/z: 320 (M+1).

후처리

  1. filtrationIt was filtered through celite
  2. washthe celite was washed with methanol
  3. customthe solvent was removed under reduced pressure
  4. customto afford the crude product which

출처 및 근거

ORD 기록
ord-711f1e37505e41bda5207720d6ccd7d1
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258306B2

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