Methylamine → HCID 10316869, 화합물

HRID 2382225노트

반응식

HRID 2382225 반응식
Cl[CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][NH2:20]>C(O)C>[CH3:19][NH:20][CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 10248728HCID 10248728, 화합물

생성물 1

HCID 10316869HCID 10316869, 화합물수율 97.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Compound 1-A (2.68 g, 7.2 mmole) was dissolved in an aqueous solution of ethanol (80 ml) and methylamine (160 ml), and heated to reflux for 30 h. After cooling, the solution was extracted with chloroform (100 ml, twice), and an organic layer was decanted. The organic layer was dried over anhydrous sodium sulfate, and dried by evaporation under vacuum, to obtain the product as oil (2.75 g, 97.4%).

후처리

  1. temperatureheated
  2. temperatureto reflux for 30 h
  3. temperatureAfter cooling
  4. extractionthe solution was extracted with chloroform (100 ml
  5. customtwice), and an organic layer was decanted
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customdried by evaporation under vacuum

출처 및 근거

ORD 기록
ord-9ea7b392a9ea418592cc53c4356f519e
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258331B2

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