Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 3-Propionylamino-pyrazine-2-carboxylic acid amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 3-Amino-2-pyrazinecarboxylic acid | HCID 72656 | — |
| 반응물 | Azane;hydrate | HCID 12896473 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Propionic anhydride | HCID 31263 | — |
| 생성물 | 3-Propionylamino-pyrazine-2-carboxylic acid amide | HCID 59993513 | 43% |
반응 단계
A mixture of 3-amino-pyrazine-2-carboxylic acid (20.9 g, 0.15 mol), pyridine (29.6 g, 0.375 mol) and DMAP (1.83 g, 15 mmol) in propionic acid anhydride (100 mL) was stirred at room temperature overnight. The reaction mixture was poured into NH3.H2O (500 mL) partially at 0° C. After stirred for 30 min at 0° C., the precipitated solid was filtered, washed with water, dried in air to give 3-propionylamino-pyrazine-2-carboxylic acid amide as a beige solid (12.4 g, 43%), which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642609B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-e462de6e1306463e8024cdb00ecdc717 |
| 출처 메모 | uspto-grants-2014_02 |