Water → 2-Phenylimidazo[1,2-c]pyrimidin-7-amine

HRID 2382753

반응식

HRID 2382753 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([O-])(O)=O.[Na+].[NH2:16][C:17]1[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]=1.O>CO>[C:5]1([C:3]2[N:16]=[C:17]3[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]3[CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6259Phenacyl bromideHCID 79608Pyrimidine-4,6-diamineHCID 516892Sodium Bicarbonate

생성물 1

HCID 4040512-Phenylimidazo[1,2-c]pyrimidin-7-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux (3 h)
  3. temperatureUpon cooling
  4. customThe precipitated title compound (5.62 g, 59%)
  5. customwas isolated by filtration
  6. washwashed with small amounts of water and methanol
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-f762f6e39be34334ba4d306d890f157c
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263584B2

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