Cycloheptylamine → HCID 25216187, 화합물

HRID 2382767노트

반응식

HRID 2382767 반응식
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([NH:19][C:2]2[N:7]3[N:8]=[C:9]([NH2:11])[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 2899CycloheptylamineHCID 214644135-Chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine

생성물 1

HCID 25216187HCID 25216187, 화합물수율 59%

반응 조건

온도
180 °C

실험 절차

The title compound was prepared following procedure described for intermediate A9, but starting from 5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A4), 2.88 g; 17.1 mmol; 1.0 eq.) and cycloheptylamine (14 mL) and heated at 180° C. for 1 h under microwave radiation to give the title compound as a beige oil (2.48 g; 59%). HPLC, Rt: 2.90 min. (purity 97.2%). LC/MS, M+(ESI): 292.9.

후처리

  1. customThe title compound was prepared following procedure

출처 및 근거

ORD 기록
ord-7326bd524f0742c0b4abe4664fa9e5b1
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263595B2

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