Acetyl chloride → HCID 68008288, 화합물

HRID 238280노트

반응식

HRID 238280 반응식
Cl.[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1)([O-:4])=[O:3].[C:17](Cl)(=[O:19])[CH3:18]>N1C=CC=CC=1.C(Cl)Cl>[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH:12]=1)([O-:4])=[O:3]

참가 물질

5

반응물 2

HCID 6367Acetyl chlorideHCID 67059989HCID 67059989, 화합물

생성물 1

HCID 68008288HCID 68008288, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매2회

실험 절차

4-(2-Nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (0.44 g, 1.8 mmol) was dissolved in a solution of pyridine (0.4 mL) and DCM (20 mL). Acetyl chloride (0.142 mL) was added and the mixture was stirred for 0.5 hours. The mixture was diluted with DCM (20 mL) and the organic solution washed with water then 1 N hydrochloric acid. The solution was dried with magnesium sulphate, filtered and the solvent removed by evaporation under vacuum to give the title compound as an orange oil (0.4 g). LCMS m/z 247.4 [M+H]+. R.T.=3.70 min (Analytical Method 4).

후처리

  1. washthe organic solution washed with water
  2. dry with materialThe solution was dried with magnesium sulphate
  3. filtrationfiltered
  4. customthe solvent removed by evaporation under vacuum

출처 및 근거

ORD 기록
ord-5af842cb979c44fd9d7473cd794a1b74
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642621B2

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