1-Benzyl-4-piperidone → 1-Benzyl-4-methylpiperidin-4-ol

HRID 238286노트

반응식

HRID 238286 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][Mg]Br.[Cl-].[NH4+]>C1COCC1.CCOCC>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH3:15])([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 192201-Benzyl-4-piperidoneHCID 25517Ammonium ChlorideHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 108459131-Benzyl-4-methylpiperidin-4-ol

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1-benzyl-4-piperidone (26.5 mmol, 5 g) in THF (50 mL) was cooled to −15° C. and a solution of methyl magnesium bromide in ether (3 M, 22 mL) was added. The mixture was stirred for 0.5 hours then allowed to warm to room temperature. Saturated aqueous ammonium chloride (50 mL) was added and the products were extracted into ethyl acetate, dried over magnesium sulphate, filtered and the solvent removed by evaporation under vacuum to give the title compound as a pale yellow solid (5.0 g) that was used directly without further purification.

후처리

  1. extractionthe products were extracted into ethyl acetate
  2. dry with materialdried over magnesium sulphate
  3. filtrationfiltered
  4. customthe solvent removed by evaporation under vacuum

출처 및 근거

ORD 기록
ord-7c4bdb5ed68c4c7db9fbbf0069da3577
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642621B2

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