Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Morpholinonicotinoyl Chloride → N-[5-(cyclohexylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-6-morpholin-4-ylnicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Morpholinonicotinoyl Chloride | HCID 2776461 | — |
| 반응물 | N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine | HCID 25216186 | — |
| 생성물 | N-[5-(cyclohexylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-6-morpholin-4-ylnicotinamide | HCID 59437487 | — |
반응 단계
The title compound was prepared following procedure described for intermediate B1, but starting from N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A9), 174 mg; 0.75 mmol; 1.0 eq.) and 6-morpholinonicotinoyl chloride (255 mg; 1.12 mmol; 1.5 eq.) as a white solid (15 mg, 5%). HPLC, Rt: 2.83 min. (purity 99.0%). LC/MS, M+(ESI): 422.2, M−(ESI): 420.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08263595B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-0c6dbc99625f4589afc87b0796503f30 |
| 출처 메모 | uspto-grants-2012_09 |