Oxane-4-carbonyl chloride → HCID 25214987, 화합물

반응식

[CH:1]1([NH:8][C:9]2[N:14]3[N:15]=[C:16]([NH2:18])[N:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:19]1[CH2:24][CH2:23][CH:22]([C:25](Cl)=[O:26])[CH2:21][CH2:20]1>>[CH:1]1([NH:8][C:9]2[N:14]3[N:15]=[C:16]([NH:18][C:25]([CH:22]4[CH2:23][CH2:24][O:19][CH2:20][CH2:21]4)=[O:26])[N:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

참가 물질

반응물 2

HCID 2795505Oxane-4-carbonyl chloride

HCID 25216187HCID 25216187, 화합물

생성물 1

HCID 25214987HCID 25214987, 화합물

실험 절차

The title compound was prepared following procedure described for intermediate B1, but starting from N5-cycloheptyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A10), 50 mg; 0.20 mmol; 1.0 eq.) and tetrahydro-2H-pyran-4-carbonyl chloride (45 mg; 0.30 mmol; 1.5 eq.) as a white solid (33 mg, 46%). HPLC, Rt: 3.02 min. (purity 96.9%). LC/MS, M+(ESI): 358.0, M−(ESI): 356.0.

출처 및 근거

ORD 기록: ord-90f6a422cd1748cb8f04cc3b54ae69cf
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08263595B2

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