Water → 4-(Bromomethyl)-N-methylbenzenesulfonamide

HRID 2382933노트

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HRID 2382933 반응식
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Cl.[CH3:14][NH2:15].O>C(Cl)Cl>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:15][CH3:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 27344094-(Bromomethyl)benzenesulfonyl chlorideHCID 6364545Methylamine hydrochloride

생성물 1

HCID 100156454-(Bromomethyl)-N-methylbenzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To a chilled (0° C.) stirred solution of 4-(bromomethyl)-benzenesulfonylchloride (3.0 g, 11 mmol) in DCM (100 mL) was added methylamine hydrochloride (1.2 g, 12 mmol). After 30 minutes, water (100 mL) was added. The organic layer was separated, washed with brine (30 mL), and dried over sodium sulfate and concentrated in vauco to afford 4-bromomethyl-N-methyl-benzenesulfonamide.

후처리

  1. customThe organic layer was separated
  2. washwashed with brine (30 mL)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vauco

출처 및 근거

ORD 기록
ord-4b9410be52a34c02a5e9b936ebade2bb
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263597B2

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