Diethanolamine → N,N-di-(2-hydroxyethyl) 3-(N-vinylformamido)propionamide

HRID 2383

반응식

HRID 2383 반응식
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10]C)=O)[CH:4]=[O:5])=[CH2:2].[NH:12]([CH2:16][CH2:17][OH:18])[CH2:13][CH2:14][OH:15].C[O-].[Na+]>CO>[OH:15][CH2:14][CH2:13][N:12]([CH2:16][CH2:17][OH:18])[C:8](=[O:10])[CH2:7][CH2:6][N:3]([CH:1]=[CH2:2])[CH:4]=[O:5]

참가 물질

5

반응물 3

HCID 8113DiethanolamineHCID 10942334Sodium MethoxideHCID 10964771methyl 3-(N-vinylformamido)propionate

생성물 1

HCID 53864890N,N-di-(2-hydroxyethyl) 3-(N-vinylformamido)propionamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
90 °C

실험 절차

A 50 mL single-neck round bottom flask equipped with a distillation head was charged with 15.1 grams (0.096 mole) of methyl 3-(N-vinylformamido)propionate, 9.95 grams (0.09 mole) of diethanolamine and 0.15 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 2 hours and the generated methanol was removed by distillation at reduced pressure. Both proton NMR and GC analyses indicated approximately a 90% conversion to the titled product.

후처리

  1. customA 50 mL single-neck round bottom flask equipped with a distillation head
  2. customthe generated methanol was removed by distillation at reduced pressure

출처 및 근거

ORD 기록
ord-5d0de86ea40e4c07a7ac73d256823ecf
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728878

연결된 노트

불러오는 중…