Pyridinium chloride → HCID 86626164, 화합물
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Cl.N1C=CC=C[CH:3]=1.[C:8]([O:12][C:13](=[O:39])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:28]=2)[N:23]=[CH:22][C:21]=1[NH2:38])([CH3:11])([CH3:10])[CH3:9]>C1(C)C=CC=CC=1>[C:8]([O:12][C:13](=[O:39])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:20]2[C:29]3[CH:28]=[C:27]([O:30][CH2:31][C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:26]=[CH:25][C:24]=3[N:23]=[CH:22][C:21]=2[N:38]=[CH:3]1)([CH3:11])([CH3:9])[CH3:10]참가 물질
4
실험 절차
For Examples 70-72, the following procedure was used. Under a nitrogen atmosphere, the reagent from the table below (1.5 equivalents) and pyridine hydrochloride (0.01-0.02 equivalents) were added to a solution of tert-butyl{4-[3-amino-6-(benzyloxy)quinolin-4-ylamino]butyl}carbamate (29-36 mmol, 1 equivalent) in toluene (200 mL), and the reaction was heated at reflux for three to five hours. The toluene was removed under reduced pressure. The residue was dissolved in a small amount of toluene, which was removed under reduced pressure. This was repeated three times. The resulting solid was dried under high vacuum at 100° C. to provide the tert-butyl{4-(8-benzyloxy-1H-imidazo[4,5-c]quinolin-1-yl]butyl}carbamate with the substituent indicated in the table below.