Toluene → HCID 178419490, 화합물

HRID 2383426노트

반응식

HRID 2383426 반응식
[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].C1(C)C=CC=CC=1>O1CCOCC1>[F:22][C:23]([F:28])([F:27])[C:24]([O-:26])=[O:25].[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][NH2+:10][CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 178451611HCID 178451611, 화합물

생성물 1

HCID 178419490HCID 178419490, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To tert-butyl 1-bromo-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carboxylate (0.23 g, 0.43 mmol) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred at room temperature for 30 minutes. On completion of the reaction, toluene (3 mL) and 1,4-dioxane (2 mL) were added and the solvents removed under reduced pressure. The crude product, 1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate was obtained as brown foam and was used in the next step without any further purification. LCMS [M+H]: 253.

후처리

  1. additionwere added
  2. customthe solvents removed under reduced pressure

출처 및 근거

ORD 기록
ord-8f5cb8fa8ca84106a09a80ddd7f0c789
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263610B2

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