Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1,1-Trifluoro-2-methylpropan-2-ol → 4-Nitrophenyl 1,1,1-Trifluoro-2-Methylpropan-2-yl-carbonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1,1-Trifluoro-2-methylpropan-2-ol | HCID 68182 | — |
| 반응물 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-Nitrophenyl 1,1,1-Trifluoro-2-Methylpropan-2-yl-carbonate | HCID 57785183 | — |
반응 단계
To a solution of 1,1,1-trifluoro-2-methylpropan-2-ol (1.0 g) in THF (30 mL) was added a 2M solution of n-butyl lithium in n-hexane (3.9 mL) and then 4-nitrophenyl chloroformate (2.4 g) at −75° C. The mixture was warmed to room temperature and diluted with ethyl acetate, washed with water, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (0-50% EtOAc/Hexane) to give 4-nitrophenyl 1,1,1-trifluoro-2-methylpropan-2-yl carbonate as a pale yellow foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08263632B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-3bf51f7a5c41482e8f8af026c33c8c4c |
| 출처 메모 | uspto-grants-2012_09 |