Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Diaminocyclohexane, trans- → 1-(2-Methyl-benzooxazol-5-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 5-Bromo-2-methyl-1,3-benzoxazole | HCID 10104599 | — |
| 반응물 | 1-(4-Methylpyridin-3-yl)imidazolidin-2-one | HCID 59636170 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-(2-Methyl-benzooxazol-5-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one | HCID 59636154 | 16.5% |
반응 단계
Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 0.1 g, 0.00057 mol) was reacted with 5-bromo-2-methyl-benzooxazole (0.119 g, 0.000597 mol), 1,4-dioxane (20 mL), copper iodide (0.01 g, 0.000057 mol), trans-1,2-diamino cyclohexane (0.019 g, 0.00017 mol) and potassium phosphate (0.242 g, 0.00114 mol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3), followed by preparative HPLC afforded 29 mg of the product (16% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08263635B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-8aadb2481d894338ab783c56c2e14970 |
| 출처 메모 | uspto-grants-2012_09 |