Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 1-Bromo-2-butanone | HCID 13156 | — |
| 반응물 | 6-Aminobenzothiazole | HCID 68288 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 1-(Benzothiazol-6-ylamino)-butan-2-one | HCID 59636195 | 34.1% |
반응 단계
Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08263635B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-7adb840d11424fd2a79c0e22e8c79c41 |
| 출처 메모 | uspto-grants-2012_09 |