Formamidine acetate → 6-(4-Methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile

HRID 2383981

반응식

HRID 2383981 반응식
C[O-].[Na+].C(O)(=O)C.[CH:8]([NH2:10])=[NH:9].C[O:12][C:13]([CH:15]1[CH2:20][C:19]([C:36]#[N:37])([C:21]2[C:29]3[C:28]4[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=4[O:26][C:25]=3[C:24]([O:34][CH3:35])=[CH:23][CH:22]=2)[CH2:18][CH2:17][C:16]1=O)=O>CO>[CH3:35][O:34][C:24]1[C:25]2[O:26][C:27]3[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=3[C:29]=2[C:21]([C:19]2([C:36]#[N:37])[CH2:18][CH2:17][C:16]3[N:10]=[CH:8][NH:9][C:13](=[O:12])[C:15]=3[CH2:20]2)=[CH:22][CH:23]=1

참가 물질

5

반응물 3

HCID 160693Formamidine acetateHCID 10942334Sodium MethoxideHCID 247555955-Cyano-5-(4-methoxy-dibenzofuran-1-yl)-2-oxo-cyclohexane carboxylic acid methyl ester

생성물 1

HCID 1356204896-(4-Methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
65 °C

실험 절차

To a stirred solution of sodium methoxide (185.3 mg, 3.5 mmol) in 10 ml of methanol was added formamidine acetate (290 mg, 2.78 mmol) and the compound obtained in example 1. The reaction mass was allowed to stir at 60-70° C. for 18 hrs under nitrogen atmosphere. Most of the methanol was evaporated under vacuum and residue was purified by column chromatography to get 200 mg (67.3% yields) of the product.

후처리

  1. customMost of the methanol was evaporated under vacuum and residue
  2. customwas purified by column chromatography
  3. customto get
  4. custom200 mg (67.3% yields) of the product

출처 및 근거

ORD 기록
ord-bb868b052bed4346b895d9499c67da39
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263648B2

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