(E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester → 4-(2-Methyl-benzothiazol-6-yl)-butyric acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:17])[CH2:4]/[CH:5]=[CH:6]/[C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([CH3:14])[S:13][C:9]=2[CH:8]=1>C1COCC1.[Pd]>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([CH3:14])[S:13][C:9]=2[CH:8]=1참가 물질
4
실험 절차
Next, a solution of (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester in THF (10 mL) is hydrogenated over 10% Pd/C (22 mg, 10% wet) at 1 atm for 48 hours. The catalyst is filtered through Celite and the solvent is removed under reduced pressure. The residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give 4-(2-methyl-benzothiazol-6-yl)-butyric acid methyl ester. MS 250.4 (M+1).
후처리
- filtrationThe catalyst is filtered through Celite
- customthe solvent is removed under reduced pressure
- customThe residue is purified by flash chromatography (heptane:EtOAc, 2:1)
출처 및 근거
- ORD 기록
- ord-53f2d3ce3a2d4b97bd49d7b01491772c
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08263629B2
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