Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate → {5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid

HRID 2384137

반응식

HRID 2384137 반응식
C([O:3][C:4](=[O:30])[CH2:5][S:6][C:7]1[S:8][C:9]([NH:12][C:13]([N:15]([CH:23]2[CH2:28][CH2:27][CH:26]([CH3:29])[CH2:25][CH2:24]2)[CH:16]2[CH2:21][CH2:20][CH:19]([CH3:22])[CH2:18][CH2:17]2)=[O:14])=[N:10][N:11]=1)C.CC1CCC(NC2CCC(C)CC2)CC1.C(OC(=O)CSC1SC(N)=NN=1)C>>[CH3:29][CH:26]1[CH2:25][CH2:24][CH:23]([N:15]([CH:16]2[CH2:17][CH2:18][CH:19]([CH3:22])[CH2:20][CH2:21]2)[C:13](=[O:14])[NH:12][C:9]2[S:8][C:7]([S:6][CH2:5][C:4]([OH:30])=[O:3])=[N:11][N:10]=2)[CH2:28][CH2:27]1

참가 물질

4

반응물 3

HCID 351912Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetateHCID 4172284-methyl-N-(4-methylcyclohexyl)cyclohexan-1-amineHCID 66871997{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid ethyl ester

생성물 1

HCID 57883670{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid

실험 절차

{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid ethyl ester prepared from bis-(4-methyl-cyclohexyl)-amine and ethyl-2-[5-amino-1,3,4-thiadiazol-2-yl-thio]acetate as described in general procedures (A) and (B). Hydrolysis using general procedure (F) gave the title compound.

후처리

  1. customHydrolysis

출처 및 근거

ORD 기록
ord-2bd09c67432c49d59b8d628f858581cf
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263634B2

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