Nitroindoline → 2,3-dihydro-1H-indol-1-amine

HRID 238416노트

반응식

HRID 238416 반응식
[N+:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)([O-])=O>[Pd]>[NH2:1][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

참가 물질

3

반응물 1

HCID 21959507Nitroindoline

생성물 1

HCID 27609322,3-dihydro-1H-indol-1-amine

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Alternatively, substituted amino-indolines 67 are prepared from the nitroindoline 62. Nitroindoline 62, is reacted with an acid chloride to form an amide. Further treatment with a primary or secondary amine, preferably a secondary amine, such as in the presence of NaI, at a temperature above about 50° C., and preferably at about 70° C. yields the nitroindoline 65. The nitro compound 65 is hydrogenated, such as with H2 in the presence of a catalyst, such as Pd/C, to yield the amino-indoline 66. The carbonyl is reduced, such as with BH3-THF yields 1-aminoalkyl-indolines 67.

출처 및 근거

ORD 기록
ord-54e50ead3fc4452d9ce41fc3c76d90cb
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642624B2

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