5-Aminothiazole 2-mercaptoacetic acid ethyl ester → HCID 178461387, 화합물
반응식
C([O:3][C:4](=[O:27])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:23]2[CH2:26][CH2:25][CH2:24]2)[C@H:16]2[CH2:21][CH2:20][C@H:19]([CH3:22])[CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(N[C@H]2CC[C@H](C)CC2)CCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:23]1([N:15]([C@H:16]2[CH2:17][CH2:18][C@H:19]([CH3:22])[CH2:20][CH2:21]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:27])=[O:3])=[CH:8][N:9]=2)[CH2:26][CH2:25][CH2:24]1참가 물질
4
실험 절차
{2-[3-Cyclobutyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cyclobutyl-(trans-4-methyl-cyclohexyl)-amine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.
후처리
- customHydrolysis