5-Bromo-2-acetylsalicylic acid → 2-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamide

반응식

[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)(=[O:3])[CH3:2].[NH2:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1>>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([NH:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1)=[O:9])(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 739225-Bromo-2-acetylsalicylic acid

HCID 178601934,5-Diethyloxazol-2-amine

생성물 1

HCID 178601192-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamide

실험 절차

Using 2-acetoxy-5-bromobenzoic acid and 2-amino-4,5-diethyloxazole as the raw materials, the same operation as the example 24 gave the title compound. (2-Acetoxy-5-bromobenzoic acid: refer to Eur. J. Med. Chem., 1996, 31, 861.)

출처 및 근거

ORD 기록: ord-457a9fcf1fbe47efbd7ca054e719ce2e
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08263657B2

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