5-Methylsalicylic acid → N-[2,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-5-methylbenzamide

HRID 2384395노트

반응식

HRID 2384395 반응식
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:15]=1[NH2:16]>>[F:12][C:13]([F:25])([F:26])[C:14]1[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][C:15]=1[NH:16][C:7](=[O:9])[C:6]1[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=1[OH:11]

참가 물질

3

반응물 2

HCID 69735-Methylsalicylic acidHCID 7198182,5-Bis(trifluoromethyl)aniline

생성물 1

HCID 59014820N-[2,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-5-methylbenzamide수율 1.5%

실험 절차

Using 5-methylsalicylic acid and 2,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

출처 및 근거

ORD 기록
ord-6dac18ef84764fdb98e97ee4f53b30ae
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263657B2

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