5-Chlorosalicylic Acid → 5-Chloro-N-[2-fluoro-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide

HRID 2384405노트

반응식

HRID 2384405 반응식
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:14]=1[NH2:15]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:15][C:14]1[CH:16]=[C:17]([C:20]([F:21])([F:22])[F:23])[CH:18]=[CH:19][C:13]=1[F:12])=[O:9]

참가 물질

3

반응물 2

HCID 94475-Chlorosalicylic AcidHCID 1363492-Fluoro-5-(trifluoromethyl)aniline

생성물 1

HCID 178601635-Chloro-N-[2-fluoro-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide수율 77.9%

실험 절차

Using 5-chlorosalicylic acid and 2-fluoro-5-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

출처 및 근거

ORD 기록
ord-bd028a3b1551461c8367b924b04067f6
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263657B2

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