Sodium Acetate → 2-(4-Methoxy-benzyl)-4,4-dimethyl-7-nitro-3,4-dihydro-2H-isoquinolin-1-one

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Acetate	HCID 517045	—
반응물	2-Bromo-N-(4-methoxy-benzyl)-N-(2-methyl-allyl)-5-nitro-benzamide	HCID 21959376	—
반응물	HCID 178526064	HCID 178526064	—
촉매	Tetraethylammonium Chloride	HCID 5946	—
용매	Dimethylformamide	HCID 6228	—
생성물	2-(4-Methoxy-benzyl)-4,4-dimethyl-7-nitro-3,4-dihydro-2H-isoquinolin-1-one	HCID 21959362	—

반응 조건

온도	70 °C

반응 단계

2-Bromo-N-(4-methoxy-benzyl)-N-(2-methyl-allyl)-5-nitro-benzamide (23.4 mmol) was dissolved in DMF (150 ml) and Et4NCl (4.25 g), HCO2Na (1.75 g) and NaOAc (4.99 g) were added. N2 was bubbled through the solution for 10 min, then Pd(OAc)2 (490 mg) was added and the mixture was stirred overnight at 70° C. The mixture was extracted with EtOAc, washed with sat'd NH4Cl, dried over MgSO4, filtered and concentrated until the compound precipitated as a white solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08642624B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-c816db6b3c624860987d23ab4a725fad
출처 메모	uspto-grants-2014_02