Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 1-Methyl-4-piperidinemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | 4-Piperidinemethanol | HCID 420771 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-Methyl-4-piperidinemethanol | HCID 271971 | — |
반응 단계
To a solution of 4-piperidylmethanol (1.0 g, 8.7 mmol) and HCHO (2 mL, 25 mmol, 37% in H2O) in CH3CN was added NaCNBH3 (0.5 g, 12.5 mmol). The resulting mixture was stirred for 1 h and filtered. The filtrate was concentrated and the residue was distilled (105° C., 40 torr) to give the title intermediate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642624B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-cbf6007db3ec4fcd92703db4737489df |
| 출처 메모 | uspto-grants-2014_02 |