Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Fluoro-4-(methylsulphonyl)benzene → [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Fluoro-4-(methylsulphonyl)benzene | HCID 67994 | — |
| 반응물 | (6-Chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326538 | — |
| 반응물 | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| 생성물 | [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326613 | 33.4% |
반응 단계
Starting with (6-chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (132 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 33%) was obtained as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642629B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-a59767866add42b69dd7390a8d6045d1 |
| 출처 메모 | uspto-grants-2014_02 |